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KMID : 0616120180490010001
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 1 p.1 ~ p.6
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Chemical Constituents from the Aerial Parts of Artemisia absinthium and Its Inhibitory Effects of Nitric Oxide Production in RAW264.7 and BV2 Microglia
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Ko Hae-Ju
Lee Hwan
Lee Dong-Sung
Woo Eun-Rhan
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Abstract
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Six compounds, eupatilin (1), dammaradienyl acetate (2), glutinol acetate (3), 3β-acetoxyoleanan-12-one (4), taraxasterol
(5) and quercetin-3,4'-dimethyl ether (6) were isolated from the aerial parts of Artemisia absinthium. The chemical structures of compounds 1-6 were determined by the basis of physico-chemical properties and spectroscopic methods such as 1D and 2D NMR. Among them, compounds 2-5 were isolated from this plant for the first time. The inhibitory effects of these isolated compounds against nitric oxide (NO) production in LPS-induced RAW264.7 cells or BV2 microglia were also examined. Among the tested compounds, compound 1, eupatilin, inhibited the production of NO in LPS-induced RAW264.7 cells and BV2 microglia, respectively.
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KEYWORD
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Artemisia absinthium , Aerial parts , Compositae , RAW264.7 cells , BV2 microglia
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